Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has been used and is fast becoming a treatment of choice for patients suffering from blood cancers like leukemia and lymphoma
Sickle cell disease (SCD) is a severe hereditary blood disorder that poses a significant public health challenge in India, particularly in regions with high malaria rates, known as the "sickle belt," which extends from West Bengal, Orissa, Jharkhand, Madhya Pradesh, Chhattisgarh, and Bihar to Maharashtra and Gujarat.
Our body is made up of cells, and whatever happens to it—good or bad—happens at a cellular level. Cancer, for example, occurs due to a small change in the cell that prompts it to proliferate abnormally. Also, cancer spreads in the body because the immune cells lose their ability to identify the danger cancer cells pose and stop them from growing. We treat cancer by surgically removing the cancer cells from the body or by giving drugs that kill the malignant cells.
Gene editing, particularly with CRISPR-Cas9 technology, has shown potential to revolutionise medicine by offering cures for a range of genetic disorders, especially blood disorders such as sickle-cell anaemia.
Navdeep Kaur is chirpy, her eyes bright as she watches a movie on her tablet during the last cycle of chemotherapy at BLK Hospital in Delhi. So contagious is her cheerfulness that her grandmother Gurmail Kaur, who is sitting beside her, is hardly nervous.